Carre Otis was raised in San Francisco along with her older sister Chrissie and her younger brother Jordan. Both of her parents were alcoholics and when she was ten, Carre began drinking herself. Carre attended Marin Academy in San Rafael, California and the John Woolman School in Nevada City, California.
Carre began modeling at age 16 and was a top model from 1988-1992. At 18, she was already a cocaine and heroin addict. She appeared on the covers and in a number of layouts in major fashion magazines, sometimes in sheer tops, topless or completely nude. She was on the covers of American Vogue September 1988, December 1988 (with Linda Evangelista), and March 1989. She was also on the covers of UK Vogue June 1989, July 1989, American Cosmopolitan June 1989, American Mirabella December 1989 and February 1995, Brazilian Marie Claire 1992, Yugoslavian Duga magazine April 1994, German GQ October 2001, New Woman September 1999, French Elle July 2004, American Harper's Bazaar January 1990 & January 1992, and UK Harper's Bazaar January 1990, just to name a few.